Meet: Kenneth M. Baldwin, Ph.D.
Professor of Physiology & Biophysics
Univerity of California, Irvine
Dr. Baldwin's laboratory research focuses on the impact of activity
patterns or exercise regimens on the biochemical and physiologic properties
of cardiac and skeletal muscle in mammals. His research has demonstrated
that muscle systems are in a dynamic state of biological adaptation, referred
to as plasticity. Various subcellular components and proteins can be changed
both qualitatively and quantitatively in accordance with how the muscle
system is continually stressed (or unstressed) by activities such as chronic
locomotion, muscle loading and unloading. Of primary interest is how the
effects of these various activities are translated into biochemical events
that lead to alterations in protein expression in muscle. Because the
role of myosin is both a structural and regulatory protein involved in
muscle contraction, work in Dr. Baldwin's laboratory focuses on factors
that influence the expression of different isoforms of myosin in both
cardiac and skeletal muscle. As a corollary to these experiments, Dr.
Baldwin's group, in conjunction with NASA, recently sent rats on a Space
Shuttle mission to study the effects of weightlessness on skeletal muscle.
Students performing research in Dr. Baldwin's laboratory receive training
in muscle physiology, biochemistry, and exercise physiology. Additional
training in the supplementary techniques of protein chemistry, cell biology,
and molecular biology is readily available and encouraged.